![]() Ketones lead to the release of another crucial molecule called BDNF (brain-derived neurotrophic factor). This signals the body to burn ketones instead of glucose as fuel (aka metabolic flexibility discussed above). When we fast for longer than twelve hours, an important metabolic switch is flipped. While the science and theories are heavily influenced by animal model studies, many argue that fasting for long term health span and healthy ageing is highly effective in humans too. īut is this any way to live a fulfilled life? Sounds to me like those mice were going hungry… It has been known since the early 1930s that significant calorie restriction in rodent studies leads to an increased lifespan and slowed ageing, albeit at the expense of restricted body size and development. Typically, people with issues such as SIBO, systemic inflammation, food allergies, indigestion or GERD, diverticulitis or IBD (ulcerative colitis and Crohn’s) flare-ups.īy giving your gut a rest from fasting, you can in fact aide in gut health and allowing it time to repair - simple!įasting for autophagy (a cellular cleanup) is being touted as a key to longevity (the increase in life and importantly health span) and staving off the degenerative effects of ageing. Some people need to give these villi a rest. When we eat food or consume calories, digestive enzymes are mobilised. They work to break things down with the small components being absorbed into your bloodstream through your small intestine walls (that are covered in villi). This means no secretion of hormones or enzymes related to digestion and no nutrient absorption. To improve your gut health, sometimes you need to give your gut a rest. Well, restoring the balance between our fed (insulin high) state and fasted (insulin low) state is likely one of the most critical levers when it comes to good metabolic health and a healthy amount of body fat. In simple terms, if you don't eat, your body should be able to mobilise stored fats for fuel and get you to your next meal – which could be hours or even days away.Īs the cliché goes… 'it is all about balance'. We're metabolically inflexible rather than metabolically flexible. Think of it as an in-built long-term fuel tank that should be readily accessible when required.īut in the vast majority of us, it isn't. It is essential to realise that body fat is simply energy that has been stored away, ready for when it is called upon - such as in times of famine and food scarcity. 'Conventional' wisdom ( we're looking at you fitness industry) has labelled body fat as something to be vilified – an enemy that we must burn. Fasting regulates the hormone insulin which is the key hormone involved in the storage and combustion of food and stored energy (aka body fat). The very foundation of fasting is to simply allow the body to mobilise and use its stored energy such as body fat and make use of ketones. There is nothing new about the use of intermittent fasting (or intermittent eating as we like to call it) in the pursuit of optimal health.Īrguably it is probably humanity's worst kept secrets to good metabolic health and humans have evolved to do it without any detriment to health - quite the opposite in fact.
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